MetaCure

GLP-1 Receptor Agonists

GLP-1 is a hormone normally produced in the small intestine and secreted in response to food consumption. GLP-1 induces β-cells in the pancreas to release insulin in response to a meal and by that sets in motion the correct metabolic response for food consumption. Recently, synthetic analogues of GLP-1 called GLP-1 receptor agonists have been introduced into clinical practice for treatment of diabetes and work by increasing the release of insulin from the pancreas. These agents need to be injected once or twice daily. In addition to their desired effect they may also cause a decrease in gastric motility, responsible for the common side-effect of nausea and vomiting. GLP-1 receptor agonists are also associated with increased risk of pancreatitis.